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Early human pilot studies reported significant adverse events including nausea, yawning, and spontaneous erection from MC4R stimulation

Human clinical trials typically report mild gastrointestinal disturbances and occasional allergic reactions, but rare cases of elevated liver enzymes have been noted, underscoring the need for cautious use, especially in individuals with preexisting liver conditions (92, 93)

In practice, it seems better to tailor the choice to different patients, depending on the preference of the route of administration (oral vs injectable), the presence of intolerance or side-effects, and contraindications

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