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Because TB-500 is often overexpressed in malignant cells and facilitates angiogenesis, there is a theoretical risk that it could accelerate the growth of dormant tumors or increase metastatic capacity in certain cancer phenotypes

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When faster or more effective healing is needed, evidence-based medical therapies include platelet-rich plasma (PRP) therapy, corticosteroid injections (with appropriate clinical guidance), approved anti-inflammatory medications, and in some cases, surgical intervention