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Prolonged overdose symptoms without medical intervention may result in acute kidney injury or elevated liver enzymes, detectable only through laboratory testingwhich is why emergency evaluation remains critical

The FDA advises individuals with personal or family histories of medullary thyroid cancer against taking the drug

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Because losing at least 5% of fasting body weight through lifestyle intervention during the 4- to 12-week run-in was a condition for their continued participation in the randomized treatment period, the results may not reflect those expected in the general population