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Retatrutide is a single peptide formulated to activate 3 metabolic hormone receptors at once: GLP-1 receptor agonism: This may slow gastric emptying, increases satiety signals to the brain, enhances glucose-dependent insulin secretion GIP receptor agonism: This enhances insulin secretion and may improve fat metabolism in preclinical models Glucagon receptor agonism: This may increase energy expenditure and hepatic fat oxidation in research settings Retatrutide works by mimicking 3 gut / liver hormones to increase insulin, reduce appetite, slow digestion, and raise energy burn

Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly Weeks 13-16: 10 mg once weekly Weeks 17-21: 12.5 mg once weekly Weeks 21-24: 15 mg once weekly

For the deep dives, see What Is AOD-9604

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