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It must be highlighted that rat skeletal muscle TC increases ~ 5070% following 4 weeks of LC supplementation [33, 34], whereas comparable elevation has never been observed in human studies, even after 24 weeks of supplementation [5, 7]
In the meantime, I believe we can all agree that it is best to administer the lowest effective dose possible, monitor duration of use and to urge our patients to be diligently aware of the presence of acetaminophen in OTC products
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