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[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency
Daily administration is reserved for specific anti-inflammatory models where continuous cytokine suppression is the primary endpoint, but most mechanisms show no additional benefit from daily versus every-other-day dosing
Each injection remains 2.8 mg while frequency falls
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