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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)
Switching between injectable and oral forms, or adjusting compounding concentrations through 503A pharmacies, provides options unavailable in standard clinical practice
fMRI data will be explored using Regional Homogeneity (ReHo) and rsFC analyses to assess local and whole-brain changes
For patients currently seeking treatment for obesity or type 2 diabetes in the UK, NICE-approved options include structured lifestyle interventions, orlistat, and more recently semaglutide (Wegovy, NICE TA875) and tirzepatide (Mounjaro, NICE TA1026) for eligible patients through NHS specialist weight management services
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