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These GLP-1 agonists can be a two-in-one solution for diabetes and weight loss, Robert Fontana, MD, a Michigan Medicine hepatologist said in an online interview, maybe a three-in-one solution if they prove to be safe and effective for metabolic associated steatohepatitis as well. When asked about the benefits observed in patients using GLP-1RA medications for conditions other than diabetes, the top five areas of improvement that physicians reported included weight loss (92 percent), positive effects on lipid profiles (57 percent), reduced cravings or dependency behaviors (56 percent), reduced blood pressure (48 percent), and reduced inflammation (46 percent)

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Its half maximal inhibitory concentration (IC50) for GIPR is 42.4 nM, and its EC50 for GLP-1R is 24.4 pM in a human cell-based functional assays (74)