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For employers, the combination of high prices and long-term use raises serious questions about sustainability

Researchers found that those who started GLP-1 drugs were 10% less likely to visit the emergency department and 14% less likely to be hospitalized over the following year, compared to those starting topiramate - a standard preventive migraine medication

Suggested User Titration (non-medical): Week 14: 2.0mg Week 58: 4.0mg Week 8+: Increase as tolerated (max 12.0mg) Side Effects to Expect Nausea (especially weeks 12) Constipation or diarrhoea Loss of appetite Low energy or flat mood (some users report) Very rare reports include vision changes, gallbladder issues, and heart rate elevation

So in many studies that ends up being 20 to 30% fewer calories