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Nonetheless, there is a gap in information regarding the substantial contribution of fat intake to obesity, which potentially acts as a precursor to the development of T2D, as opposed to the intake of other macronutrients

Until it is, statistics will continue to be derived from case reports and review articles that reflect the opinion of those authors

Together, these studies highlight the complex interplay between CKD, neuroinflammation, and gut-derived signals, providing strong evidence that the gut microbiota and its metabolites play a significant role in promoting neuroinflammatory processes in CKD, which in turn contribute to cognitive decline and neurodegenerative changes

Alterations in IGF-1R downstream signaling molecules such as PI3K/AKT are reported in various cancers 33,34