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Tua hyperphosphorylation: ROS and RNS contribute to the abnormal phosphorylation of Tua proteins, lose capacity to bind to brain cell microtubule, and bind to each other, tying themselves in knots, leading to neurofibrillary tangles (NFTs)

Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice

16 Interestingly, one patient had some abnormal changes in the elastic fibers and another patient had some excess of elastic fibers

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