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The label for tirzepatide notes that after starting treatment, clinicians should "observe patients carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back, which may or may not be accompanied by vomiting)." A Low Threshold to Stop At the Society of General Internal Medicine (SGIM) 2024 Annual Meeting in May, Mohammed Abdelsalam, MD, a resident at Texas Tech University Health Sciences Center in Amarillo, Texas, presented a case of necrotizing pancreatitis and cholecystitis in a 25-year-old woman taking tirzepatide for weight loss