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Confirms the reversal is causal, not just correlational

Results showed that after treatment, those in the semaglutide group consumed lower amounts of alcohol in the laboratory, as measured by grams of alcohol consumed and breath alcohol concentration

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

However, in some cases, the reduction in appetite and subsequent weight loss can be excessive, leading to concerns about undernutrition or fatigue