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PMCID: PMC11890406

Girges C, Vijiaratnam N, Athauda D, Auld G, Gandhi S, Foltynie T

In mammals, excess purine nucleosides are removed from the body by breakdown in the liver and excretion from the kidneys

Using these probes in yeast, we show that even during severe oxidative stress, the cytosolic glutathione disulfide (GSSG) concentration is much more tightly regulated than expected and provides a mechanistic explanation for the discrepancy with conventional measurements

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