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The SURPASS clinical trial program, which evaluated tirzepatide for type 2 diabetes over periods extending to 52 weeks and beyond, demonstrated sustained glycemic improvements without evidence of significant tachyphylaxis (rapid tolerance development) for the primary glucose-lowering effects

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Similar patterns were observed for SGLT-2 inhibitors during the initial exposed period (0-12 months) and the late exposed period (13-24 months)

This matches the recommended concentration for 10mg vials reconstituted with 2mL, so the dosing charts above apply directly