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The weight loss drug market has evolved into one of the most explosive, flourishing segments of the global healthcare industry, driven by an unprecedented surge in demand for glucagon-like peptide-1 (GLP-1) receptor agonists

Semaglutide to tirzepatide Switching from semaglutide to tirzepatide is the most common transition, typically motivated by a desire for greater weight loss or a plateau on semaglutide

Prespecify mechanistic endpoints, include appropriate comparators, and ensure diverse, representative populations

The rapid weight loss associated with these medications can include significant lean mass loss if protein intake is inadequate