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Aberrant proteins exceeding the processing ability of mitochondrial chaperones are degraded into peptides by the matrix protease ClpP, transported to the IMS via heat shock factor-1, and then enter the nucleus through the action ATFS-1, thereafter stimulating the transcription of chaperone genes to prevent excessive aggregation of misfolded proteins (Fig

Use in woundhealing and tissueinjury models : Investigated in rat subcutaneous wound chambers and skininjury paradigms, to assess effects on connectivetissue accumulation, angiogenesis, inflammatory markers, and antioxidant enzyme activity

Certain medical conditions, such as cancer, HIV/AIDS, type 2 diabetes, hepatitis, and Parkinsons disease, can also deplete glutathione levels