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4.2 GSH/GSSG Imbalance in Aging and Neurodegenerative Disease Because the brain has high energy demand, abundant oxidizable lipids, and strong dependence on mitochondrial function, glutathione metabolism is frequently studied in aging and neurodegeneration

Nevertheless, as these models allow controlling the medium flow, dynamic BBB models were successfully applied for the investigation of the ischemia-induced injury (Cucullo et al., 2008) and antiepileptic drugs (Cucullo et al., 2007)

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