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Hypertensive patients have been observed to produce high levels of hydrogen peroxide, superoxide anion, and NO in leukocytes [290,291,292], exhibit elevated lipid peroxidation in erythrocytes, and display elevated concentrations of 8-isoprostanes in plasma [293]
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As IGF-1 LR3, being a modified and more powerful version of natural IGF-1, reproduces these effects without affecting levels of growth hormone secretion by the pituitary gland itself
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