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Advantages No injection required Simple, convenient administration May provide some local benefit to the gastrointestinal tract before degradation Easier for people with needle aversion Disadvantages Substantially lower systemic bioavailability Inconsistent absorption from dose to dose Higher doses needed to achieve similar systemic effects (if achievable at all) Limited evidence for systemic benefits via oral route Potential GI effects from higher doses Emerging Solutions Some manufacturers are exploring encapsulation technologies, enteric coatings, and liposomal delivery systems designed to protect oral peptides from digestive degradation

A separate cohort study including 101 Black women living in South Africa found statistically significant weight gain through 48 weeks of follow-up after switching to DOR from EFV- or dolutegravir-based regimens [27, 28]