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2 Exhibit 1: US market penetration vs projected market size In the most recent wave of developments, Novo secured an FDA label expansion for Wegovy for cardiovascular risk reduction (a key step toward medicalizing reimbursement beyond cosmetic weight loss) and, importantly for premiumization, also announced approval of a once-daily oral Wegovy option potentially widening adoption among injectionaverse patients while intensifying competition in convenience-led segments

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Exposure to temperatures above 30C is not recommended according to the SmPC