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William Bundy Jr., PharmD | ToxiPharm LLC #ClinicalToxicology #PharmD #ToxiPharm #ToxPearl #Medetomidine #FentanylAdulterants #OpioidWithdrawal #AddictionMedicine #OTP #SubstanceUseDisorder #EmergencyMedicine #MOUD #DrugSupply #PatientSafety #UrineDrugTesting To view or add a comment, sign in An important update for colleagues working in opioid pharmacotherapy

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After starting and after each dose increase, tirzepatide can cut the peak absorption of an oral contraceptive by more than half, so the label guidance is a non-oral method or added barrier protection for four weeks after starting and four weeks after each increase. It is a first-dose-and-escalation effect, not a permanent block on all oral drugs

This cycling approach serves multiple purposes: it prevents potential receptor desensitization, maintains copper homeostasis, and allows assessment of results before continuing