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The treatment group showed significant reductions in body weight (approximately 5% loss) and white adipose tissue mass (35% reduction) compared to control animals, despite no changes in food intake
Oral supplementation retains measurable activity in gastric-origin animal models, reflecting the peptide's natural stability within the gastrointestinal environment
Furthermore, dihydrobiopterin plays a role in maintaining the reduced state of tetrahydrofolate, so the clinical phenotype of dihydrobiopterin deficiency is similar to that of dihydrofolate reductase deficiency
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