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While this typically means morning administration for many patients, the critical factor is taking it before the first intake of the day, which may be at different times for shift workers
In women with PCOS, high concentrations of leptin have been reported to inhibit the expression of aromatase mRNA in granulosa cells, while the hyperandrogenic follicular environment in GCs was found to significantly reduce the expression of P450arom, which can convert androgens into estrogen, further increasing the levels of androgens and ultimately promoting follicular atresia (148150)
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If blood sugar targets are not being met effectively on one medication, the dual action of tirzepatide might provide superior glucose management
