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In addition, the immunomodulatory potentiality of these compounds to trigger T helper type 1 (Th1) cells and cytokine-mediated immune response for the substantial induction of proinflammatory cytokines, thus, Se, selenoproteins, and parasite selenoproteins could be further investigated to find possible vaccine antigens

88 More broadly, this highlights an underappreciated principle in the field: ferroptotic propagation is shaped not only by intracellular biochemistry but also by tissue-scale geometry and extracellular spatial constraints, linking molecular reactions to anatomical structure

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