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5 #4 Avoid prolonged sun exposure Prolonged sunlight exposure can degrade glutathione levels in the skin, reducing its effectiveness as an antioxidant and diminishing its skin health benefits
Serious but Rare Side Effects Both medications carry warnings for more serious but uncommon side effects, occurring in less than 1-2% of patients: Pancreatitis (inflammation of the pancreas) Kidney problems Severe allergic reactions Thyroid tumors (seen in animal studies) Gastroparesis (delayed stomach emptying) Serious stomach issues Vision problems in some diabetics Retatrutides side effect profile appears similar to that of other incretin-based medications, though long-term safety data remains limited due to its investigational status
Additionally, several next-generation GLP-1 therapies are in late-stage development, offering new administration methods and expanded indications in 2026
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