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This property has led to its investigation as a therapeutic agent for addressing skin conditions, notably in individuals with fair skin or increased sensitivity to ultraviolet (UV) radiation
Another factor involves metabolic differences between individuals
"Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study"
Use extra caution if you have a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, or diabetic retinopathy
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