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Magnus etal, 1986, 1991) For over 60 years it has been known that Vitamin B12 sufficiency is crucial for the development of myelination of the central nervous system, and poor vitamin B12 status is linked to poor growth and neurodevelopment (Gutierrez-Diaz, 1959

However, with the shortage resolved, the FDA expects these compounded versions to be phased out, as they are not FDA-approved and may pose safety risks

That bioavailability hurdle is why different delivery systems (liposomal, sustained-release, S-acetyl, sublingual) exist, and why choosing the right form matters as much as choosing the right brand

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