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PMCID: PMC4113756

Strengths and Limitations Strengths: Brightens skin quickly Improves skin texture Limitations: Can irritate sensitive skin Unstable in poor formulations Best Pigmentation Types Mild hyperpigmentation Dull and tired-looking skin Complementary Effects Vitamin C enhances glutathione activity and improves its absorption, making them an effective combination

Results Validation Success: Method validated per ICH M10 guidelines for 1500 ng/mL range Stability: Demonstrated 64-day stability at both 20C and 80C Selectivity: Chromatograms free of interferences across all plasma types Matrix Effects: Assay free of matrix effects across all plasma types

Both classes of drugs leverage the bodys natural hormone systems to promote weight loss but do so through distinct mechanisms