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It was decided to leave it like that due to the possibility of upper lip paralysis

View study Krivic A, Anic T, Seiwerth S, et al

5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed

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