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Among the PC subtypes, the mesenchymal-like subtype, primarily PANC-1 and MIA PaCa-2 cell lines, exhibits enhanced aerobic glycolytic activity and reduces matrix, collagen and activated PSC content by secreting CSF-1, which is beneficial to reduce the mechanical limitation in the tumour matrix and is associated with a worse clinical prognosis
Dulaglutide is distinguished by a positive safety record with rare occurrences of serious adverse effects
Specifically, the FDAs decision not to include these GLP-1s on the bulk compounding list would not be expected to affect their use by 503A pharmacies
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