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different GLP1-RA were prescribed throughout the study according to the GLP1-RA agent approved within the VHA at time of prescription (Supplemental Table S6)

Pros of naturally boosting GLP-1: No side effects No risk of long-term dependency Minimal cost with no barriers to care Provides benefits beyond GLP-1 activity (due to lifestyle changes in diet) Easy to incorporate into any lifestyle Cons of natural GLP-1: Natural GLP-1 persists for a short amount of time in the bloodstream (a few minutes) Effects vary from person to person Results arent as fast or as dramatic Can be more difficult to see dramatic and rapid results with diet and lifestyle changes alone Note: Because GLP-1 production happens naturally, there are no negative effects per se

The primary difference between ipamorelin sellers is transparency and verification , not availability

[1] It is a GLP-1 receptor agonist