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Data-dependent MS2 fragmentation for compound identification and annotation was performed via the AquireX workflow (Thermo Scientific), which comprised three deep scans with MS1 resolution at 60,000 and MS2 resolution at 15,000

This structural feature contributes to orforglipron's selectivity for the GLP-1 receptor over other incretin receptors, a property that distinguishes it from multi-receptor agonists like tirzepatide and retatrutide

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The depletion of body fluids also results in a lack of necessary electrolytes