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Endothelial cells comprise the inner monolayer of blood vessels that forms a barrier between the artery wall and circulating blood is responsible for regulating vascular tone, regulation of hemostatic properties on the vascular surface, and determining blood-tissue/brain permeability (Paschos and FitzGerald, 2010)

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So if they had tested the group and excluded any subjects with in range blood results, would they have gotten the same results in the trial

A deficiency can, therefore, lead not only to the central nervous system manifestations seen in Wernicke encephalopathy but also to peripheral sensorimotor neuropathy, characterized by weakness, numbness, and pain in the extremities