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The processes of mitochondrial fusion, fission, and mitophagy are balanced in the normal brain
US 2014342399, Thoen, Marcel & Schloesser, Thomas, "Microorganism and method for overproduction of gamma -glutamylcysteine and derivatives of this dipeptide by fermentation", published 2014-11-20, assigned to Wacker Chemie AG EP 1489173, Nishiuchi, Hiroaki
From a translational perspective, this timing-dependent action may represent an advantage, as ALS patients generally start therapeutic interventions only once clinical symptoms are already manifest, and modeling treatment at symptomatic onset therefore provides a scenario that closely mirrors the real-world conditions of patient care