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High-density SNP array analysis of the parent tumor showed copy number gains spanning most of chromosomes 2, 5, 6, 7, 8, 11, 17 and 19, with large regions of gain also present that involved distal 1q, 3q, 4q, 9q, 10q, 12p, 13q, 15q, 16q, proximal 20p, 20q, 21q, 22q and the proximal part of Xp and Xq (Supplementary Figs