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Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function

Accumulating evidence indicates that Chinese herbal compounds, active constituents, and formulated prescriptions can ameliorate ferroptosis in PCOS by remodeling the gut microbiota and modulating ferroptosis-associated pathways (Table 1)

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