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The holistic approach behind retatrutide therapy looks beyond the scale and targets more lasting health benefits, particularly for those living with multiple chronic conditions

Participants were randomized to receive either semaglutide or placebo in a 2:1 ratio, combined with a low-calorie diet for the first 8 weeks, followed by intensive behavioral therapy for 68 weeks, including 30 counseling visits

doi: 10.1038/s41467-023-37368-1 78 SousaGFCarpesRMSilvaCAOPereiraMEPSilvaACVFCoelhoVAGSet al

It typically takes 16-20 weeks to reach the maximum maintenance dose of 15 mg, as the FDA-approved schedule requires at least four weeks at each dose level during escalation