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The funder of this study had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
On the other hand, the concept of non-genomic or cytoplasmic response was introduced in 1967, when Szego and Davis observed an increase in cyclic adenosine monophosphate (cAMP) in the MCF-7 breast cancer cell line pretreated with estrogens (Szego and Davis, 1967)
404 SGT-53, a nanoparticle that has WT TP53 cDNA packed in a plasmid, was shown to inhibit tumor growth, increase the induction of apoptosis, and significantly improve median survival in patients treated in combination with temozolomide
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