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10.1007/s11684-019-0724-6 24 SugaT.KikuchiO.KobayashiM.MatsuiS.Yokota-HashimotoH.WadaE.et al (2019)
In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]
However, berberine is biologically active, not inert
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