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Research Applications MT-1 has been utilized as a molecular probe in controlled experimental systems examining: Melanocortin receptor pharmacology (MC1R, MC3R, MC4R, MC5R) Melanogenesis and pigmentation signaling pathways UV-induced DNA damage and nucleotide excision repair models Cutaneous photoprotection biology Skin inflammatory signaling and cytokine modulation Oxidative stress responses in melanocytes and keratinocytes Erythropoietic protoporphyria (EPP) photoprotection models

Moreover, an upregulation of HMOX1 favours the accumulation of Fe 2+ that can react with H 2 O 2 in a Fenton-like reaction thus producing the highly reactive ROS hydroxyl radical

Examples include: Insulin Native incretins Newer drugs such as: Tirzepatide Semaglutide How Peptides Work in the Body: Receptors and Responses Peptides bind to cell surface receptors and trigger cascades inside cells