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NAD+ levels in human skin decline with age, and this decline affects multiple repair mechanisms simultaneously: DNA repair capacity (through PARP enzyme activity), mitochondrial energy production in skin cells, autophagy of damaged proteins, including glycated collagen, and the sirtuin-mediated preservation of collagen integrity
It was first isolated in 1974 from cerebral venous blood during induced sleep states
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Huang, G., Zhang, Y., Zhang, Y
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