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Lipolysis Enhancement and Lipogenesis Inhibition In obese Zucker rats, daily oral administration of AOD9604 significantly increased lipolytic activity in adipose tissue compared to controls, establishing direct adipocyte-level lipolysis stimulation as a key mechanism of action in pre-clinical models

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In it, the researchers administered MOTS-c to mice at various life stages young (two months old), middle-aged (12 months old), and old (22 months old) and saw that subjects at every life stage exhibited improved physical performance in multiple tests, including those assessing motor coordination and running capacity.21 The findings arent dissimilar to a 2023 study in humans, which found that a higher serum MOTS-c concentration correlated with greater muscle mass, force, and power generated during jumping in healthy subjects.22 Reduced inflammation A 2024 study on mature mice points to MOTS-cs potential as a treatment for acute and chronic inflammatory disorders