when to titrate up on tirzepatide titration schedule feels arbitrary current dose is still working : r/Mounjaro Microdosing tirzepatide chart: complete week-by-week

Dong Y, Wang S, Zhang T, Zhao X, Liu X, Cao L, et al

Their membrane integrity was compromised, and cristae were fragmented, blurred, reduced, or absent, accompanied by a less dense matrix with uneven electron density and vacuolar changes

Other drugs are available that work similarly to semaglutide

In a cerebrospinal fluid (CSF) substudy, participants receiving semaglutide exhibited modest yet statistically significant reductions (in the range of 10% or less) in several key biomarkers associated with Alzheimers disease (AD) pathology and neurodegeneration, including phosphorylated tau181 (p-tau181), phosphorylated tau217 (p-tau217), total tau, and the neuroinflammatory marker YKL-40 levels