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Patient-specific risk factors include: Personal or family history of nephrolithiasis : Individuals with prior kidney stones have a recurrence rate of approximately 50% within 510 years, making this the strongest predictor of future stone formation

We hypothesized that if melatonin suppresses ILC2s via NRF2 activation, then pharmacological activation of NRF2 with DMF should phenocopy the effects of melatonin

Additional contraindications include a history of serious hypersensitivity reactions to tirzepatide or any of its components