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Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139
The side effect profile is not trivial
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Terpstra, M., Torkelson, C., Emir, U., Hodges, J
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