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On the other hand, chronic hyperglycemia due to IR leads to increased extracellular and intracellular formation of advanced glycation end products (AGEs), leading to detrimental effects, including increased oxidative stress and production of inflammatory cytokines in these brain cells (125)
Phase 2 trial data showed weight loss of up to 24% at the highest dose, with phase 3 trials underway
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These medications carry an FDA boxed warning about potential thyroid C-cell tumor risk based on animal studies
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