However, studies evaluating the role of omega-3 PUFA-based nutraceuticals in the setting of thyroid disorders, reached inconclusive results [133]
Still, the preservative has limits
demonstrated that ellagic acid exhibits local analgesic effects in rats in a dose-dependent manner during both the early and late phases of the formalin test, highlighting its action through the L-arginine/NO/cGMP/K ATP pathway (Ghorbanzadeh et al., 2014)
First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate