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58 Even after a 17-week off-treatment follow-up period post-trial, while some weight regain occurred (~7%) and some metabolic benefits diminished, significant net improvements compared to baseline remained

Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73

Symptoms may include dizziness or lightheadedness, blurred vision, mood changes, sweating, slurred speech, hunger, confusion, drowsiness, shakiness, weakness, headache, rapid heartbeat, or feeling jittery

[2] [3] Semaglutide is not indicated for type 1 diabetes treatment