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27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication

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MEDVi says its clinician-guided model pairs patients with board-certified physicians who evaluate the clinical differences between these medications and match patients to the option most likely to align with their health profile and goals